Nature rune

Nature Rune is a free-to-play item on the OSRS Grand Exchange in the runes category.

In-game examine text: "Used for alchemy spells."

It has a Grand Exchange buy limit of 18,000 every four hours, a high alchemy value of 108 gp, and item ID 561.

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Nature Rune currently has a flip margin of +0 gp, which isn't profitable to flip right now despite 26,818,998 trades over the last 24 hours.

Items with negative or zero margins like this are better watched than actively flipped until the spread widens.